Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
نویسندگان
چکیده
2-Naphthyl-substituted glucopyranosylidene-spiro-oxathiazole prepared following a novel design principle was found to be the best known glucose analogue inhibitor of rabbit muscle glycogen phosphorylase b (K(i) 160 nM).
منابع مشابه
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 18 20 شماره
صفحات -
تاریخ انتشار 2008