Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.

نویسندگان

  • László Somsák
  • Veronika Nagy
  • Sébastien Vidal
  • Katalin Czifrák
  • Eszter Berzsényi
  • Jean-Pierre Praly
چکیده

2-Naphthyl-substituted glucopyranosylidene-spiro-oxathiazole prepared following a novel design principle was found to be the best known glucose analogue inhibitor of rabbit muscle glycogen phosphorylase b (K(i) 160 nM).

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 18 20  شماره 

صفحات  -

تاریخ انتشار 2008